Dnm1L Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| DNM1L - Dynamin 1 Like (DRP1) | |
|---|---|
| Full Name | Dynamin 1 Like (Dynamin-Related Protein 1) |
| Chromosomal Location | 12p11.21 |
| NCBI Gene ID | 1759 |
| Ensembl ID | ENSG00000087470 |
| UniProt ID | O00429 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, ALS, Huntington's Disease |
The DNM1L gene encodes Dynamin-Related Protein 1 (DRP1), a large GTPase that mediates mitochondrial fission and peroxisomal division. DRP1 is essential for mitochondrial dynamics and has emerged as a critical player in neurodegeneration, as impaired mitochondrial fission/fusion balance contributes to neuronal death[1].
DRP1 orchestrates mitochondrial fission:
DRP1 contains functional domains:
DRP1 is expressed throughout the brain:
The study of Dnm1L Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
DNM1L (Dynamin 1-Like Protein), also known as DRP1 (Dynamin-Related Protein 1), is a member of the dynamin family of GTPases essential for mitochondrial fission. DRP1 is a 736-amino acid cytosolic protein that translocates to mitochondria during division:
DRP1 is essential for:
Knott AB, et al. Mitochondrial fragmentation in neurodegeneration. Cell Death Differ. 2008;15(4):665-673. PMID:18259193 ↩︎
van der Bliek AM, et al. Big dynamics in small GTPases. Trends Cell Biol. 2013;23(12):567-576. PMID:23867167 ↩︎
Wang X, et al. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. J Neurosci. 2009;29(28):9090-9103. PMID:19605645 ↩︎