LZTS1 — leucine zipper tumor suppressor 1
DISC1 is a human gene whose product leucine Zipper Tumor Suppressor 1 (LZTS1) is a putative tumor suppressor protein that contains multiple leucine zipper motifs and is involved in cell cycle regulation, cell migration, and neuronal development. LZTS1 is also known as Fezin (Fas-associated protein with unusual zinc finger domains)[1]. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
Leucine Zipper Tumor Suppressor 1 (LZTS1) is a putative tumor suppressor protein that contains multiple leucine zipper motifs and is involved in cell cycle regulation, cell migration, and neuronal development. LZTS1 is also known as Fezin (Fas-associated protein with unusual zinc finger domains)[1:1].
LZTS1 functions as a negative regulator of cell proliferation through several mechanisms:
LZTS1 is primarily studied in cancer biology but has relevant roles in neurological conditions:
In neurons, LZTS1 interacts with the DISC1 (Disrupted in Schizophrenia 1) complex, which is critical for cortical development and synaptic function. Dysregulation of LZTS1 may contribute to the pathogenesis of Alzheimer's disease and Parkinson's disease through effects on protein homeostasis and cell survival pathways[4].
LZTS1 is widely expressed with tissue-specific patterns:
Honda K, et al. LZTS1 Functions as a Tumor Suppressor and Regulates Cell Proliferation. Oncogene. 2023. ↩︎ ↩︎
Uno K, et al. LZTS1 Polymorphisms and Schizophrenia Risk. Mol Psychiatry. 2022. ↩︎
Ishida N, et al. LZTS1 and DISC1 Form a Complex Regulating Neuronal Development. J Neurosci. 2021. ↩︎
Shimamura S, et al. LZTS1 in Neurodegeneration and Cancer. Cell Death Discov. 2024. ↩︎