SERPINA3 encodes alpha-1 antichymotrypsin, a serine protease inhibitor that is upregulated in acute inflammation. It is expressed in astrocytes and has been implicated in Alzheimer's disease pathogenesis as an acute-phase reactant that can interact with amyloid-beta plaques.
| Property | Value |
|---|---|
| Gene Symbol | SERPINA3 |
| Gene Name | Serpin Family A Member 3 (Alpha-1 Antichymotrypsin) |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 12 |
| OMIM | 107450 |
| UniProt | P01011 |
SERPINA3 encodes alpha-1 antichymotrypsin, a serine protease inhibitor that is upregulated in acute inflammation. It is expressed in astrocytes and has been implicated in Alzheimer's disease pathogenesis as an acute-phase reactant that can interact with amyloid-beta plaques.
The SERPINA3 gene is associated with the following neurodegenerative and related diseases:
SERPINA3 expression and its relevance to brain function is under active investigation.