| UBR5 — Ubiquitin-Protein Ligase E3 Component N-Recognin 5 | |
|---|---|
| Symbol | UBR5 |
| Full Name | Ubiquitin-Protein Ligase E3 Component N-Recognin 5 |
| Chromosome | 8q22.3 |
| NCBI Gene | 51366 |
| Ensembl | ENSG00000146233 |
| UniProt | O95071 |
| Diseases | [ALS](/diseases/amyotrophic-lateral-sclerosis), [Cancer](/diseases/cancers), Developmental disorders |
| Expression | Ubiquitous, Brain (high), Testis |
UBR5 (Ubiquitin-Protein Ligase E3 Component N-Recognin 5), also known as E3 ubiquitin-protein ligase UBR5 or EDD1, is a HECT-type E3 ubiquitin ligase located on chromosome 8q22.3. It is a member of the N-recognin family of E3 ligases, which recognize substrates bearing N-terminal (N-end rule) degradation signals[1]. UBR5 plays critical roles in protein quality control, cell cycle regulation, DNA damage response, and has been implicated in neurodegenerative diseases.
UBR5 is a HECT-domain E3 ubiquitin ligase with multiple cellular functions:
The N-end rule pathway recognizes proteins based on their N-terminal amino acid residues. UBR5:
UBR5 is essential for clearing misfolded and damaged proteins:
UBR5 plays important roles in DNA repair:
UBR5 controls cell cycle progression:
UBR5 has been implicated in ALS pathogenesis[2]:
UBR5 is frequently amplified or overexpressed in cancers:
It functions as an oncogene, promoting:
UBR5 variants have been associated with:
UBR5 is ubiquitously expressed with highest levels in:
UBR5 interacts with several key pathways: