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| Symbol | NCX1 |
| Full Name | Sodium Calcium Exchanger 1 |
| Chromosome | 2p23.3 |
| NCBI Gene | 6576 |
| OMIM | 604527 |
| Ensembl | ENSG00000155380 |
| UniProt | P32418 |
| Associated Diseases | Cardiac disease, ischemia |
NCX1 is a gene encoding a protein involved in ion transport that plays important roles in neuronal function and has been implicated in neurodegenerative diseases.
The NCX1 gene encodes a protein that is part of a family of ion transporters critical for maintaining ionic homeostasis in neurons. These proteins are essential for proper neuronal excitability, calcium signaling, and cellular viability.
Ion transporters maintain the electrochemical gradients necessary for neuronal function. The NCX1 protein contributes to cellular homeostasis and has been studied in the context of excitotoxicity, calcium dysregulation, and neurodegenerative processes in Alzheimer's and Parkinson's disease.
NCX1 (SLC8A1) encodes the sodium-calcium exchanger 1, a crucial ion transporter that exchanges 3 Na+ for 1 Ca2+ across the plasma membrane. It is essential for calcium homeostasis in neurons and cardiac myocytes.
NCX1 (SLC8A1) is a sodium-calcium exchanger that transports 3 Na+ and 1 Ca2+. Important for calcium homeostasis in neurons and cardiac cells.
High expression in heart and brain.