| GRB2 — Growth Factor Receptor Bound Protein 2 | |
|---|---|
| Symbol | GRB2 |
| Full Name | Growth Factor Receptor Bound Protein 2 |
| Chromosome | 17q25.1 |
| NCBI Gene | 2885 |
| Ensembl | ENSG00000177885 |
| OMIM | 108355 |
| UniProt | P62993 |
| Diseases | [AD](/diseases/alzheimers), [PD](/diseases/parkinsons-disease), [ALS](/diseases/als), cancer (driver) |
| Expression | Ubiquitous ([neurons](/entities/neurons), glia, all tissues) |
GRB2 (Growth Factor Receptor Bound Protein 2) is a critical adaptor protein that links receptor tyrosine kinases to downstream signaling pathways[1][2]. This page provides detailed information about its structure, function, and role in neurodegeneration.
GRB2 is an adaptor protein encoded by the GRB2 gene on chromosome 17q25.1. It contains one SH2 domain flanked by two SH3 domains, allowing it to link activated receptor tyrosine kinases (RTKs) to the RAS/MAPK and PI3K/AKT signaling cascades[^3]. GRB2 is essential for cellular proliferation, differentiation, survival, and synaptic plasticity.
GRB2 serves as a molecular adaptor:
GRB2 is involved in:
GRB2 binds to activated Trk receptors (TrkA, TrkB, TrkC) linking NGF, BDNF, and NT-3 signaling to neuronal survival pathways.
GRB2 is frequently amplified or overexpressed in cancers:
GRB2 is ubiquitously expressed:
[Schlessinger. Cell signaling by receptor tyrosine kinases](https://doi.org/10.1016/S0092-8674(00). Cell. 2000. ↩︎
Margolis et al. The SH2 and SH3 domains of the growth factor receptor-bound protein 2 (GRB2) are selectively mutated in the mammalian cell transformation. Oncogene. 1992;7(11):2219-2228. PubMed:1314964. 1992. ↩︎