The MYT1L gene encodes Myelin Transcription Factor 1-like, a zinc finger transcription factor crucial for neuronal differentiation and development. MYT1L is a key driver of neuronal fate commitment and is essential for the differentiation of neurons from progenitor cells.
| Attribute | Value |
|---|---|
| Symbol | MYT1L |
| Full Name | Myelin Transcription Factor 1 Like |
| Chromosomal Location | 2p25.3 |
| NCBI Gene ID | 23040 |
| OMIM | 613084 |
| Ensembl ID | ENSG00000116254 |
| UniProt | Q9UL36 |
MYT1L is a transcription factor with multiple zinc finger domains that binds to DNA and regulates gene expression:
| Disease | Mechanism | Evidence |
|---|---|---|
| Alzheimer's Disease | MYT1L is downregulated in AD brains; loss of neuronal identity genes contributes to neurodegeneration | PMID: 29507854 |
| Parkinson's Disease | Altered MYT1L expression affects dopaminergic neuron survival | PMID: 27878467 |
| Intellectual Disability | MYT1L haploinsufficiency causes neurodevelopmental disorders | PMID: 25644679 |
MYT1L and related transcription factors are being explored for: