Fbp1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Fructose-1,6-bisphosphatase 1 | |
|---|---|
| Gene Symbol | FBP1 |
| Full Name | Fructose-1,6-bisphosphatase 1 |
| Chromosome | 9q22.33 |
| NCBI Gene ID | 2203 |
| OMIM | 229700 |
| Ensembl ID | ENSG00000165140 |
| UniProt ID | P09467 |
| Associated Diseases | Fructose-1,6-bisphosphatase Deficiency, Cancer |
FBP1 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of FBP1 is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
FBP1 encodes fructose-1,6-bisphosphatase 1, a key enzyme in gluconeogenesis that catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate. While primarily expressed in liver and kidney, FBP1 also has tumor suppressor functions in various cancers. In the brain, it may play roles in metabolic regulation.
Expressed in liver, kidney, and various tissues. Low expression in most brain regions.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| FBPase Deficiency | Missense | Autosomal recessive | Impaired gluconeogenesis |
The study of Fbp1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.