TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a neuronal-specific non-selective calcium-permeable cation channel highly expressed in the brain. It plays crucial roles in synaptic plasticity, neuronal development, and cognitive functions.
| Symbol | TRPC5 |
|---|---|
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 5 |
| Chromosomal Location | Chromosome Xq23 |
| NCBI Gene ID | [7225](https://www.ncbi.nlm.nih.gov/gene/7225) |
| OMIM | [300334](https://www.omim.org/entry/300334) |
| Ensembl ID | ENSG00000120336 |
| UniProt ID | [Q9P9X1](https://www.uniprot.org/uniprot/Q9P9X1) |
| Associated Diseases | Intellectual disability, Autism spectrum disorder, Epilepsy |
TRPC5 is a member of the TRPC (Transient Receptor Potential Canonical) family with unique neuronal expression patterns and functions. It operates as a non-selective cation channel permeable to Ca²⁺, Na⁺, and K⁺ 1. [1]
Key functional characteristics: [2]
TRPC5 exhibits brain-specific expression: [3]
The channel localizes to dendritic shafts and spines, where it modulates synaptic signaling and plasticity 13.
TRPC5 is a promising drug target for:
TRPC5 in mood disorders (2014). 2014. ↩︎
TRPC5 neuroprotection (2014). 2014. ↩︎