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| Symbol | HRH1 |
| Full Name | Histamine Receptor H1 |
| Chromosome | 3p25 |
| NCBI Gene | 3373 |
| OMIM | 147783 |
| Ensembl | ENSG00000135740 |
| UniProt | P35367 |
| Associated Diseases | Allergies, cognitive function |
HRH1 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The HRH1 gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The HRH1 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in HRH1 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
HRH1 encodes the histamine H1 receptor, a G-protein coupled receptor that mediates allergic responses and wakefulness. It is widely distributed in the brain, particularly in the thalamus and cortex, and is a target for classic antihistamine drugs.
HRH1 encodes the H1 histamine receptor. Couples to Gq and mediates allergic responses. Also involved in wakefulness and cognition.
Widely expressed in brain and peripheral tissues.