Osmr Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-gene
| Gene Symbol | OSMR |
| Full Name | Oncostatin M Receptor |
| Chromosomal Location | 5p13.1 |
| NCBI Gene ID | 9184 |
| OMIM | 601743 |
| Ensembl ID | ENSG00000120708 |
| UniProt | Q08357 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Inflammatory Bowel Disease |
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OSMR encodes the Oncostatin M receptor (OSMR), a component of the IL-6 family cytokine receptor signaling. OSMR forms heterodimeric complexes with either GP130 (for OSM signaling) or IL6ST to mediate responses to Oncostatin M (OSM) and other IL-6 family cytokines. OSMR signaling contributes to neuroinflammation and is implicated in neurodegenerative diseases.
OSMR is a type I cytokine receptor:
OSMR is implicated in AD:
OSMR signaling in PD:
OSMR may play a role in ALS:
OSMR is expressed on:
In the brain, OSMR is primarily expressed on glial cells, particularly astrocytes.
The study of Osmr Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.