Max — Myc Associated Factor is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| MAX Gene | |
|---|---|
| Full Name | MAX Protein |
| Chromosome | 14q23.3 |
| NCBI Gene ID | 4149 |
| OMIM | 154040 |
| Ensembl ID | ENSG00000125952 |
| UniProt ID | P61275 |
| Description | Transcription factor, Myc/Max/Mad network member |
| Associated Diseases | Neuroblastoma, Burkitt Lymphoma, Prostate Cancer, Alzheimer's Disease |
MAX is a transcription factor that forms heterodimers with MYC to activate gene expression or with MAD to repress transcription. This Myc/Max/Mad network regulates cell proliferation, differentiation, and apoptosis. In neurons, MAX plays roles in synaptic plasticity and neuronal survival. Dysregulation of the Myc/Max network has been implicated in neurodegeneration and cancer.
The MAX gene encodes a basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor that functions as a master regulator of cell growth and differentiation. MAX forms heterodimers with MYC proteins to activate transcription of genes involved in cell proliferation, metabolism, and ribosome biogenesis. Alternatively, MAX can form heterodimers with MAD family proteins to repress transcription and promote differentiation.
In neurons, MAX plays critical roles in:
MAX is ubiquitously expressed including:
Expression is maintained throughout life, with high levels in metabolically active neurons.
The study of Max — Myc Associated Factor has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.