Ppp2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| PPP2R2A | |
|---|---|
| Gene Symbol | PPP2R2A |
| Full Name | Protein Phosphatase 2 Regulatory Subunit B55 Alpha |
| Chromosome | 8p21.2 |
| NCBI Gene ID | 5520 |
| OMIM | 601728 |
| Ensembl ID | ENSG00000156535 |
| UniProt ID | P63151 |
| Associated Diseases | Alzheimer's Disease, Cancer |
This page provides comprehensive information about the PPP2R2A gene and its role in neurodegenerative diseases. The gene encodes a protein involved in various molecular pathways relevant to Alzheimer's disease, Parkinson's disease, and related conditions.
PPP2R2A encodes the B55α regulatory subunit of protein phosphatase 2A (PP2A). PP2A is a major serine/threonine phosphatase with roles in:
The B55α subunit targets PP2A to specific substrates, including tau. PP2A activity is reduced in AD, contributing to tau hyperphosphorylation.
PPP2R2A is expressed in most tissues:
The study of Ppp2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
This page was created to expand the NeuroWiki gene database for neurodegenerative disease research.