RAMP1 (Receptor Activity Modifying Protein 1) is a single-pass membrane protein that associates with G protein-coupled receptors to form functional receptors for calcitonin gene-related peptide (CGRP) and related peptides.
- Symbol: RAMP1
- Full Name: Receptor Activity Modifying Protein 1
- Chromosomal Location: 2q36.1
- NCBI Gene ID: 10267
- Ensembl ID: ENSG00000132329
- UniProt ID: O60883
RAMP1 is essential for CGRP receptor formation:
- CGRP Receptor: CALCR + RAMP1
- Amylin Receptor: CALCLR + RAMP1 (AMY1)
- Vasodilation: CGRP is a potent vasodilator
- Pain Transmission: Involved in migraine and pain signaling
- Neuroprotection: CGRP has neurotrophic effects
- Energy Homeostasis: Affects metabolism through amylin signaling
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Migraine: CGRP and its receptor are primary targets for migraine prevention [1].
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Alzheimer's Disease: CGRP signaling may be neuroprotective [2].
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Pain Disorders: CGRP receptor antagonists for neuropathic pain [3].
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Stroke: CGRP has protective effects in cerebral ischemia [4].
- Sensory neurons (trigeminal, dorsal root)
- Brain (widespread)
- Cardiovascular system
- Immune cells
- Poe et al., CGRP receptor in migraine (2023)
- Russell et al., CGRP in neurodegeneration (2022)
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.