Hspb8 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
HSPB8 (Heat Shock Protein Family B Member 8), also known as Hsp22 or Hsp22-like protein, is a small heat shock protein with emerging roles in neurodegenerative diseases. It is encoded by the HSPB8 gene located on chromosome 21q22.3.
| Attribute | Value |
|---|---|
| Gene Symbol | HSPB8 |
| Full Name | Heat Shock Protein Family B Member 8 |
| Chromosomal Location | 21q22.3 |
| NCBI Gene ID | 23673 |
| Ensembl ID | ENSG00000169435 |
| UniProt ID | Q9UJX1 |
| OMIM | 607655 |
HSPB8 encodes a 196-amino acid protein with a molecular weight of approximately 22 kDa. It contains:
HSPB8/Hsp22 functions as a molecular chaperone that:
HSPB8 is expressed in:
| Approach | Status | Description |
|---|---|---|
| Small molecule activators | Research | Increase HSPB8 expression |
| Gene therapy | Research | AAV-mediated delivery |
The study of Hspb8 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.