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| Symbol | EFNA4 |
| Full Name | Ephrin A4 |
| Chromosome | 1q21.3 |
| NCBI Gene | 1945 |
| OMIM | 602020 |
| Ensembl | ENSG00000126247 |
| UniProt | P52802 |
| Associated Diseases | Synaptic plasticity |
EFNA4 (Ephrin A4) is a GPI-anchored ligand for EPHA receptors that mediates cell-cell communication and regulates synaptic plasticity. As an ephrin family member, EFNA4 plays crucial roles in neural development, synaptic function, and cellular signaling. Altered EFNA4 expression has been implicated in neurodegenerative diseases, particularly Alzheimer's disease, as well as in various cancers.
EFNA4 is an ephrin-A ligand that modulates EPHA receptor signaling. It regulates synaptic function and may contribute to memory processes.
Expressed in hippocampus and cortex.