MAP1LC3C (Microtubule-Associated Protein 1 Light Chain 3 Gamma) is a member of the LC3 family of autophagy-related proteins. MAP1LC3C plays a crucial role in autophagosome formation and the autophagy-lysosomal pathway, which is essential for clearing protein aggregates in neurodegenerative diseases.
| MAP1LC3C (LC3C) | |
|---|---|
| Gene Symbol | MAP1LC3C |
| Full Name | Microtubule-Associated Protein 1 Light Chain 3 Gamma |
| Chromosome | 4q26 |
| NCBI Gene ID | 75380 |
| OMIM | 609459 |
| Ensembl ID | ENSG00000143153 |
| UniProt ID | Q9GZU8 |
| Associated Diseases | Parkinson's Disease, Neurodegeneration with Brain Iron Accumulation |
MAP1LC3C encodes one of the microtubule-associated proteins (MAP1) light chain 3 family, also known as LC3C. LC3 proteins are essential components of the autophagosome, participating in autophagosome formation and cargo recognition. LC3C is involved in selective autophagy pathways, including mitophagy (mitochondrial autophagy) and ER-phagy. In neurons, proper autophagy function is critical for clearing protein aggregates and maintaining neuronal health.
Expressed in various tissues with notable expression in brain. LC3C has specific roles in selective autophagy pathways.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Parkinson's Disease | Risk variants | Complex | Impaired mitophagy |
| NBIA | Various | Risk factor | Dysregulated autophagy |