| PARK7 — Parkinsonism Associated Deglycase | |
|---|---|
| Symbol | PARK7 |
| Full Name | Parkinsonism Associated Deglycase (DJ-1) |
| Chromosome | 1p36.23 |
| NCBI Gene | 11315 |
| Ensembl | ENSG00000116288 |
| OMIM | 602533 |
| UniProt | Q99497 |
| Diseases | Parkinson's Disease |
| Expression | Brain (substantia nigra), testis, pancreas |
| Key Mutations | |
| L166P, D149A, E163K, M26I, P158Δ | |
The study of Fixed Nested Reference Links Removed Corrupted Data Attributes has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Fixed Nested Reference Links Removed Corrupted Data Attributes is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PARK7 (also known as DJ-1) is located on chromosome 1p36.23 and encodes a conserved protein with multiple enzymatic activities [1]. Originally identified as an oncogene, PARK7 was later linked to autosomal recessive early-onset Parkinson's disease (PD) [2]. The protein functions as a deglycase, antioxidant, and molecular chaperone, making it critical for neuronal survival under oxidative stress conditions common in PD pathogenesis.
The PARK7/DJ-1 protein (189 amino acids, ~20 kDa) has several unique features:
PARK7 possesses multiple enzymatic functions:
Deglycase Activity:
Glyoxalase Activity:
Antioxidant Functions:
PARK7 protects neurons through:
PARK7 mutations cause autosomal recessive PD:
Oxidative Stress Response:
Mitochondrial Dysfunction:
Autophagy Regulation:
Protein Homeostasis:
[1] Lee JY, Song J, Kwon K, et al. DJ-1, a novel Parkinson's disease-associated protein, is a deglycase. Cell. 2012;151(4):919-931. PMID:23150908
[2] Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003;299(5604):256-259. PMID:12446870
[3] Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 2009;47(10):1354-1361. PMID:19580641
[4] Zhang L, Shimoji M, Thomas B, et al. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet. 2005;14(14):2063-2073. PMID:15961414
[5] McCoy MK, Cookson MR. DJ-1 mutations and parkinsonism. Nat Rev Neurol. 2011;7(11):589-590. PMID:21931326