SERPINE1 encodes plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis and extracellular matrix remodeling. Elevated PAI-1 levels are associated with aging, cellular senescence, and fibrosis. It has been implicated in neurodegeneration through its effects on synaptic plasticity and neuroinflammation.
| Property | Value |
|---|---|
| Gene Symbol | SERPINE1 |
| Gene Name | Serpin Family E Member 1 (PAI-1) |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 5054 |
| OMIM | 173360 |
| UniProt | P05121 |
SERPINE1 encodes plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis and extracellular matrix remodeling. Elevated PAI-1 levels are associated with aging, cellular senescence, and fibrosis. It has been implicated in neurodegeneration through its effects on synaptic plasticity and neuroinflammation.
The SERPINE1 gene is associated with the following neurodegenerative and related diseases:
SERPINE1 expression and its relevance to brain function is under active investigation.