| PTCH1 — Patched 1 | |
|---|---|
| Symbol | PTCH1 |
| Full Name | Patched 1 (Hedgehog Receptor) |
| Chromosome | 9q22.32 |
| NCBI Gene | 5727 |
| Ensembl | ENSG00000107807 |
| OMIM | 601309 |
| UniProt | Q13535 |
| Diseases | Parkinson's Disease, Gorlin Syndrome, Basal Cell Carcinoma |
| Expression | Brain, Skin, Lung, Embryonic tissues |
Ptch1 — Patched 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PTCH1 (Patched 1) encodes the principal receptor for Hedgehog (HH) signaling molecules. PTCH1 is a 12-pass transmembrane protein that inhibits Smoothened (SMO) in the absence of Hedgehog ligands, making it a critical regulator of the Hedgehog pathway.
PTCH1 functions as the HH receptor with several key roles:
PTCH1 plays complex roles in dopaminergic neuron biology:
PTCH1 modulators are being studied for:
The study of Ptch1 — Patched 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.