Itpr1 Inositol 1,4,5 Trisphosphate Receptor Type 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Itpr1 Inositol 1,4,5 Trisphosphate Receptor Type 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Inositol 1,4,5-Trisphosphate Receptor Type 1 | |
|---|---|
| Gene Symbol | ITPR1 |
| Full Name | Inositol 1,4,5-Trisphosphate Receptor Type 1 |
| Chromosome | 3p26.1 |
| NCBI Gene ID | 3708 |
| OMIM | 147521 |
| Ensembl ID | ENSG00000150995 |
| UniProt ID | Q14643 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Spinocerebellar Ataxia, Huntington's Disease |
ITPR1 is an intracellular calcium release channel located on the endoplasmic reticulum. It releases calcium in response to IP3 binding, playing a central role in calcium signaling[^1].
ITPR1 is one of three IP3 receptor types:
ITPR1 performs essential functions:
ITPR1 is implicated in AD:
In PD:
ITPR1 mutations cause SCA15/SCA29:
ITPR1 is expressed in:
In the brain, ITPR1 is highly expressed in cerebellar Purkinje cells and hippocampal neurons.
Berridge MJ. (2009). "Inositol trisphosphate and calcium signalling." Nat Rev Mol Cell Biol. 10(2):173-183.[^1]
Oules B, et al. (2012). "IP3 receptor in AD." J Alzheimers Dis. 32(1):1-22.[^2]
Itpr1 Inositol 1,4,5 Trisphosphate Receptor Type 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Itpr1 Inositol 1,4,5 Trisphosphate Receptor Type 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.