TRIM63 (MURF-1) is a muscle-specific ubiquitin ligase highly expressed in skeletal and cardiac muscle. It plays a key role in atrophy pathways and has been implicated in muscle wasting disorders.
| Property | Value |
|---|---|
| Gene Symbol | TRIM63 |
| Gene Name | Tripartite Motif Containing 63 (MURF-1) |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 55177 |
| OMIM | 606471 |
| UniProt | Q9C0B1 |
TRIM63 (MURF-1) is a muscle-specific ubiquitin ligase highly expressed in skeletal and cardiac muscle. It plays a key role in atrophy pathways and has been implicated in muscle wasting disorders.
The TRIM63 gene is associated with the following neurodegenerative and related diseases:
TRIM63 expression and its relevance to brain function is under active investigation.