Cacna2D3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cacna2D3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CACNA2D3 (Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3) encodes a neuronal-specific auxiliary subunit of voltage-gated calcium channels.
| Property | Value |
|---|---|
| Gene Symbol | CACNA2D3 |
| Full Name | Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3 |
| Chromosomal Location | 3p21.1 |
| NCBI Gene ID | 55769 |
| Ensembl ID | ENSG00000157445 |
| UniProt | Q8WZ48 |
The CACNA2D3 gene encodes the α2δ-3 subunit, a neuronal-specific auxiliary component of voltage-gated calcium channels:
| Disease | Association Type | Key Evidence |
|---|---|---|
| Epilepsy | Risk Modulator | CACNA2D3 variants associated with absence seizures |
| Autism Spectrum Disorder | Risk Modulator | Rare variants found in ASD patients |
| Migraine | Risk Modulator | Associated with migraine with aura |
| Schizophrenia | Risk Modulator | Genetic association studies |
CACNA2D3 shows specific expression:
Cacna2D3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cacna2D3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Edelstyn E, et al. Brain 2014;137:599-609