Ifnar1 — Interferon Alpha Receptor 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ifnar1 — Interferon Alpha Receptor 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Interferon Alpha Receptor 1 | |
|---|---|
| Gene Symbol | IFNAR1 |
| Full Name | Interferon Alpha and Beta Receptor Subunit 1 |
| Chromosome | 21q22.11 |
| NCBI Gene ID | 3454 |
| OMIM | 146590 |
| Ensembl ID | ENSG00000142149 |
| UniProt ID | P17181 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, Aicardi-Goutières Syndrome |
IFNAR1 encodes the interferon alpha receptor 1, a component of the type I interferon receptor. Type I interferons (IFN-α, IFN-β) are cytokines that mediate antiviral immunity and modulate immune responses. IFNAR1 pairs with IFNAR2 to form the functional receptor complex. Signaling through this receptor activates the JAK-STAT pathway, leading to transcription of interferon-stimulated genes (ISGs). In the brain, type I interferon signaling modulates microglial activation, synaptic plasticity, and neuroinflammation.
Wide expression in immune cells (macrophages, microglia, lymphocytes). Lower expression in neurons and astrocytes. Upregulated during viral infections and in neurodegenerative disease brains.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Alzheimer's Disease | Promoter variants | Risk factor | Chronic type I interferon signaling, neuroinflammation |
| Parkinson's Disease | R89C | Risk factor | Altered microglial interferon response |
| Multiple Sclerosis | T341M | Protective | Reduced interferon signaling |
| Aicardi-Goutières Syndrome | Various | Autosomal recessive | Impaired interferon regulation |
Ifnar1 — Interferon Alpha Receptor 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ifnar1 — Interferon Alpha Receptor 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.