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| Symbol | ATP2B1 |
| Full Name | ATPase Plasma Membrane Ca2+ Transporting 1 |
| Chromosome | 12q21.33 |
| NCBI Gene | 491 |
| OMIM | 306720 |
| Ensembl | ENSG00000082068 |
| UniProt | P20020 |
| Associated Diseases | Cognitive function |
ATP2B1 is a gene encoding a protein involved in ion transport that plays important roles in neuronal function and has been implicated in neurodegenerative diseases.
The ATP2B1 gene encodes a protein that is part of a family of ion transporters critical for maintaining ionic homeostasis in neurons. These proteins are essential for proper neuronal excitability, calcium signaling, and cellular viability.
Ion transporters maintain the electrochemical gradients necessary for neuronal function. The ATP2B1 protein contributes to cellular homeostasis and has been studied in the context of excitotoxicity, calcium dysregulation, and neurodegenerative processes in Alzheimer's and Parkinson's disease.
ATP2B1 encodes PMCA1, a plasma membrane calcium ATPase crucial for calcium extrusion from neurons. It is essential for synaptic plasticity and cellular calcium homeostasis.
ATP2B1 (PMCA1) is a plasma membrane calcium ATPase. Essential for calcium extrusion from neurons.
Widely expressed in brain.