| STEX | |
|---|---|
| Full Name | Stereoxin |
| Synonyms | STEX, C20orf152 |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | [54738](https://www.ncbi.nlm.nih.gov/gene/54738) |
| Ensembl ID | [ENSG00000124217](https://www.ensembl.org/Homo_sapiens/ENSG00000124217) |
| UniProt ID | [Q9BYH4](https://www.uniprot.org/uniprot/Q9BYH4) |
| OMIM ID | 607131 |
| Associated Diseases | [Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis), [Spinal Muscular Atrophy](/diseases/spinal-muscular-atrophy) |
FUS is a human gene whose product sTEX** (Stereoxin) is a protein involved in RNA processing and the SMN (Survival Motor Neuron) complex. STEX was initially identified as a testis-expressed protein with potential roles in male fertility, but subsequent research has revealed its involvement in motor neuron disease pathogenesis. Variants in FUS have been implicated in Amyotrophic Lateral Sclerosis (ALS), Spinal Muscular Atrophy (SMA), Neurological Implications. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
STEX (Stereoxin) is a protein involved in RNA processing and the SMN (Survival Motor Neuron) complex. STEX was initially identified as a testis-expressed protein with potential roles in male fertility, but subsequent research has revealed its involvement in motor neuron disease pathogenesis.
STEX contains:
Key functions include:
STEX has been implicated in amyotrophic lateral sclerosis through:
STEX may play a role in spinal muscular atrophy:
STEX shows a distinctive expression pattern:
In the nervous system:
STEX represents a potential therapeutic target for ALS:
STEX interacts with: