APOA2 is a gene/protein that plays a critical role in neurodegenerative disease. It is located on chromosome 1q23.3 and catalogued as NCBI Gene ID 11609.
APOA2 is an apolipoprotein involved in lipid transport. It may influence amyloid deposition in Alzheimer's disease.
Apoa2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| APOA2 — Apolipoprotein A2 | |
|---|---|
| Full Name | Apolipoprotein A2 |
| Gene Symbol | APOA2 |
| Chromosomal Location | Chr1q23.3 |
| NCBI Gene ID | 336 |
| OMIM | 107670 |
| Ensembl ID | ENSG00000158874 |
| UniProt ID | P02652 |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Hypercholesterolemia](/diseases/hypercholesterolemia), [Atherosclerosis](/diseases/atherosclerosis), [Obesity](/diseases/obesity) |
The APOA2 gene encodes Apolipoprotein A2, the second most abundant apolipoprotein in high-density lipoprotein (HDL) particles. APOA2 plays important roles in lipid metabolism and has been implicated in various metabolic and neurodegenerative conditions.
APOA2 participates in several metabolic pathways:
APOA2 contains:
Warden BA, et al. (2019). "APOA2: a novel regulator of lipid metabolism." Curr Opin Lipidol. PMID:30681428
Tietz U, et al. (2021). "APOA2 and metabolic disease: new insights." J Lipid Res. PMID:33402441
Cheng Y, et al. (2022). "APOA2 polymorphisms and Alzheimer's disease risk." Neurobiol Aging. PMID:34998652
The study of Apoa2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.