APOB is a gene/protein that plays a critical role in neurodegenerative disease. It is located on chromosome 2p24.1 and catalogued as NCBI Gene ID 338.
APOB is a component of lipoproteins and is linked to lipid metabolism in the brain. Dysregulation is associated with neurodegenerative diseases.
Apob Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| APOB — Apolipoprotein B | |
|---|---|
| Full Name | Apolipoprotein B |
| Gene Symbol | APOB |
| Chromosomal Location | Chr2p24.1 |
| NCBI Gene ID | 338 |
| OMIM | 107730 |
| Ensembl ID | ENSG00000184677 |
| UniProt ID | P04114 |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Hypercholesterolemia](/diseases/hypercholesterolemia), [Atherosclerosis](/diseases/atherosclerosis), [Familial Hypercholesterolemia](/diseases/familial-hypercholesterolemia) |
The APOB gene encodes Apolipoprotein B, the main structural protein of very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) particles. APOB is essential for lipid transport and has been implicated in both cardiovascular and neurological diseases.
APOB serves critical functions in lipid metabolism:
APOB-100 is one of the largest proteins:
Sniderman AD, et al. (2014). "Apolipoprotein B vs low-density lipoprotein cholesterol as markers." JAMA. PMID:25196643
Rader DJ, Hovingh GK. (2014). "Lipoprotein(a) and cardiovascular disease." Lancet. PMID:25253126
Koudinov A, et al. (1996). "Apolipoprotein B in Alzheimer's disease brain." Lancet. PMID:8709718
Yao X, et al. (2022). "APOB and Alzheimer's disease: new insights." J Alzheimer's Dis. PMID:35180145
The study of Apob Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.