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| Symbol | TRPA1 |
| Full Name | Transient Receptor Potential Cation Channel Subfamily A Member 1 |
| Chromosome | 8q21.11 |
| NCBI Gene | 8980 |
| OMIM | 604450 |
| Ensembl | ENSG00000104321 |
| UniProt | Q8IUM7 |
| Associated Diseases | Pain, asthma, neurodegenerative disease |
TRPA1 is a gene encoding a transient receptor potential (TRP) channel that plays important roles in sensory transduction and has been implicated in neurodegenerative diseases.
The TRPA1 gene encodes a non-selective cation channel belonging to the TRP superfamily. These channels are activated by various stimuli including temperature, chemicals, and mechanical force, and contribute to cellular calcium signaling.
TRP channels are widely expressed in the nervous system and participate in sensory perception, neuroprotection, and disease processes. The TRPA1 channel has been studied in the context of oxidative stress, neuroinflammation, and neurodegenerative conditions including Alzheimer's and Parkinson's disease.
TRPA1 is a chemical-sensitive ion channel activated by irritants like mustard oil, cinnamaldehyde, and acrolein. It is expressed in sensory neurons and is involved in pain and neurogenic inflammation.
TRPA1 is an irritant-sensing channel activated by pungent compounds. Involved in neuropathic pain and neuroinflammation.
Expressed in sensory neurons and airway.