Gabra4 — Gaba A Receptor Alpha 4 Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GABRA4 (Gamma-Aminobutyric Acid Type A Receptor Alpha 4 Subunit) encodes the alpha-4 subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates inhibitory neurotransmission.
| Attribute | Value |
|---|---|
| Gene Symbol | GABRA4 |
| Full Name | GABA-A Receptor Alpha 4 Subunit |
| Chromosomal Location | 4p12 |
| NCBI Gene ID | 2567 |
| OMIM | 137140 |
| Ensembl ID | ENSG00000109180 |
| UniProt | P18507 |
The GABRA4 gene encodes the GABA-A receptor alpha-4 subunit, a 448 amino acid protein.
The alpha-4 subunit confers distinct pharmacological properties:
High expression in:
| Agent | Mechanism | Status | Indication |
|---|---|---|---|
| Diazepam | GABA-A modulator | Approved | Anxiety, seizure |
| THIP | Extrasynaptic agonist | Research | Insomnia |
The study of Gabra4 — Gaba A Receptor Alpha 4 Subunit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Rudolph U, et al. GABA-A receptor subtypes. Curr Opin Neurobiol. 1999.
[2] Möhler H. GABA-A receptor diversity. Curr Opin Pharmacol. 2006.
[3] Cheng VJ, et al. GABRA4 in neurological disorders. J Neurochem. 2010.
[4] Liu Q, et al. GABRA4 and epilepsy. Epilepsy Res. 2014.
[5] Peng H, et al. GABAergic signaling in neurodegeneration. Front Cell Neurosci. 2017.
[1] Whiting PJ, et al. GABA-A receptor subtypes: the puzzle continues. Trends Pharmacol Sci. 2021;42(8):636-650. PMID:34083172
[2] Rudolph U, Mohler H. GABA-A receptor subtypes: a new pharmacology. Curr Opin Pharmacol. 2020;52:73-79. PMID:32961482
[3] Rudolph U, et al. GABA(A) receptor subtypes: therapeutic potential in Down syndrome. Adv Pharmacol. 2022;93:37-59. PMID:35690345
[4] Braat S, Kooy RF. GABRA4 and neurodevelopmental disorders. Neurobiol Dis. 2021;155:105385. PMID:34048913
[5] Liu L, et al. Alpha4 subunit containing GABA-A receptors in neurological disease. J Neurochem. 2023;164(5):657-672. PMID:36752019