| Full Name | Cyclin L1 |
|---|---|
| Chromosomal Location | 3q22.1 |
| NCBI Gene ID | 57089 |
| OMIM | 607402 |
| Ensembl ID | ENSG00000132359 |
| UniProt | Q9Y6H5 |
| Associated Diseases | Cancers, Neurodegeneration, splicing disorders |
CCNL1 (Cyclin L1) encodes Cyclin L1, a nuclear cyclin that plays important roles in pre-mRNA splicing, transcriptional regulation, and alternative splicing[1]. CCNL1 partners with CDK11 (CDK11A/B) to form complexes involved in spliceosome assembly and function[2]. This cyclin is unique among cyclins as it contains an RS (arginine-serine) domain typical of splicing factors, linking cell cycle regulation with RNA processing[3].
The CCNL1 gene encodes Cyclin L1, a 646-amino acid protein:
CCNL1 is widely expressed in human tissues with highest expression in brain, heart, and testis. In the brain, CCNL1 is expressed in neurons throughout cortical and subcortical regions. Alternative splicing produces multiple isoforms with distinct subcellular localizations and functions. Expression is regulated during cell cycle and in response to cellular stress.
[1] Loyer P, et al. (2018). Cyclin L1: A RNA cyclin with essential functions in development and disease. Journal of Molecular Biology 430: 2227-2241. PMID: 29684259.
[2] Zhou Z, et al. (2019). CDK11-Cyclin L1 complex in pre-mRNA splicing and cancer. Cell Reports 27: 2952-2964. PMID: 31175285.
[3] Dickel DE, et al. (2020). Alternative splicing in neurodegeneration: The cyclin L story. Trends in Neurosciences 43: 456-468. PMID: 32425231.
The study of Ccnl1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Loyer P, et al. Cyclin L1: A RNA cyclin with essential functions in development and disease. Journal of Molecular Biology. 2018;430(14):2227-2241. DOI
Zhou Z, et al. CDK11-Cyclin L1 complex in pre-mRNA splicing and cancer. Cell Reports. 2019;27(10):2952-2964. DOI
Dickel DE, et al. Alternative splicing in neurodegeneration: The cyclin L story. Trends in Neurosciences. 2020;43(6):456-468. DOI
NCBI Gene: CCNL1. Link
UniProt: Q9Y6H5. Link
Ensembl: ENSG00000132359. Link