Aif Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
AIF (Apoptosis-Inducing Factor) is a flavoprotein that functions in both caspase-dependent and caspase-independent cell death pathways. It is encoded by the AIFM1 gene and plays a critical role in mitochondrial function and cell survival.
AIF is a 63 kDa protein localized to the mitochondrial intermembrane space. Under normal conditions, it functions as an NADH oxidase. Upon apoptosis induction, AIF translocates to the nucleus where it induces chromatin condensation and large-scale DNA fragmentation.
AIF contains:
AIF functions in:
AIF-mediated cell death contributes to:
The study of Aif Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.