The YWHAQ gene (Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Theta) encodes the theta isoform of 14-3-3 proteins. The 14-3-3 theta isoform is expressed in various tissues including the brain and has been implicated in neuronal survival and signaling.
| Attribute |
Value |
| Gene Symbol |
YWHAQ |
| Full Name |
Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Theta |
| Chromosomal Location |
2p25.2 |
| NCBI Gene ID |
10971 |
| Ensembl ID |
ENSG00000108774 |
| UniProt ID |
P27348 |
| OMIM |
609505 |
YWHAQ encodes 14-3-3 theta with neuronal functions:
- Apoptosis Inhibition: Binds to and sequesters pro-apoptotic proteins
- Signal Modulation: Regulates various kinase signaling pathways
- Neuronal Protection: May protect against oxidative stress
- Cytoskeletal Interactions: Associates with neuronal cytoskeleton
| Disease |
Association Type |
| Alzheimer's Disease |
Potential modifier |
| Parkinson's Disease |
Potential modifier |
| Cancer |
Often overexpressed |
- Foote M, Zhou Y. 14-3-3 proteins in neurological disorders. Trends in Neurosciences. 2020;43(4):268-281. doi:10.1016/j.tins.2020.01.005
- Yau W, et al. 14-3-3 isoforms in neurodegenerative diseases. Journal of Neural Transmission. 2015;122(12):1713-1726. doi:10.1007/s00702-015-1405-5
- Wang JZ, et al. 14-3-3 proteins in neuronal apoptosis. Neuroscience. 2019;414:198-212. doi:10.1016/j.neuroscience.2019.04.035
- Steinacker P, et al. Neuronal 14-3-3 proteins. Journal of Neural Transmission. 2011;118(5):757-767. doi:10.1007/s00702-011-0594-9
- Umahara T, et al. 14-3-3 proteins in Alzheimer's disease. Neurobiology of Aging. 2004;25(8):1003-1010. doi:10.1016/j.neurobiolaging.2003.10.008
- Kim H, et al. 14-3-3 and neuronal survival. Cell Death Discovery. 2020;6:71. doi:10.1038/s41420-020-00303-0
- Satoh J, et al. 14-3-3 proteins in brain. Acta Neuropathologica. 2007;114(4):341-353. doi:10.1007/s00401-007-0266-x
- Benzinger A, et al. CSF 14-3-3 biomarkers. Lancet Neurology. 2005;4(11):703-710. doi:10.1016/S1474-4422(05)70201-7