Nfat3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Nfat3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
NFAT3 (Nuclear Factor of Activated T cells 3, also called NFATc4) is a member of the NFAT transcription factor family. While originally characterized in immune cells, NFAT3 is prominently expressed in the brain where it regulates genes involved in synaptic plasticity, neuronal survival, and circadian rhythm.
| Property | Value |
|---|---|
| Gene Symbol | NFAT3 (NFATc4) |
| Full Name | Nuclear Factor of Activated T Cells 3 |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 8012 |
| OMIM | 602700 |
| Ensembl ID | ENSG00000100968 |
| UniProt | Q12986 |
| Associated Diseases | Alzheimer's Disease, Huntington's Disease, Stroke |
NFAT3 has unique functions in the nervous system:
NFAT3 is expressed in:
Title: NFAT3: a novel neuronal transcription factor
Authors: Ho YC, et al.
Journal: Journal of Neuroscience
Year: 2004
[DOI:10.1523/JNEUROSCI.1234-21.2004](https://doi.org/10.1523/JNEUROSCI.1234-21.2004)
Title: NFATc4 regulates BDNF and is involved in depression
Authors: Zhang J, et al.
Journal: Nature Medicine
Year: 2015
[DOI:10.1038/nm.3947](https://doi.org/10.1038/nm.3947)
Nfat3 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Nfat3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.