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| Symbol | PDE6B |
| Full Name | Phosphodiesterase 6B |
| Chromosome | 4p16.3 |
| NCBI Gene | 5159 |
| OMIM | 180072 |
| Ensembl | ENSG00000133250 |
| UniProt | P16404 |
| Associated Diseases | Retinitis pigmentosa, night blindness |
PDE6B (Phosphodiesterase 6B) is a cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and/or cAMP. Phosphodiesterases play crucial roles in regulating intracellular signaling pathways, neuronal function, and synaptic plasticity. Dysregulated PDE6B activity has been implicated in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.
PDE6B is the beta subunit of rod photoreceptor phosphodiesterase. Critical for phototransduction. Not directly related to neurodegeneration.
Exclusively expressed in retina.