| LINGO3 — Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3 | |
|---|---|
| Gene Symbol | LINGO3 |
| Full Name | Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3 |
| Chromosome | 19q13.42 |
| NCBI Gene ID | [158046](https://www.ncbi.nlm.nih.gov/gene/158046) |
| OMIM | 616233 |
| Ensembl ID | ENSG00000125845 |
| UniProt ID | [Q9H2Y7](https://www.uniprot.org/uniprot/Q9H2Y7) |
| Protein Name | LINGO3 protein |
| Associated Diseases | [Parkinson's Disease](/diseases/parkinsons-disease), [Alzheimer's Disease](/diseases/alzheimers-disease), Multiple Sclerosis |
LINGO3 is a human gene whose product LINGO3 is a member of the leucine-rich repeat and immunoglobulin-like domain (LRR+Ig) family of transmembrane proteins. It is primarily expressed in the nervous system and plays a role in neurite outgrowth and axon guidance. LINGO proteins are negative regulators of axonal regeneration. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.
Gene Symbol: LINGO3
Gene Name: Leucine-Rich Repeat and Immunoglobulin-Like Domain Containing Neurite Outgrowth Inhibitor Protein 3
NCBI Gene ID: 158046
UniProt ID: Q9H2Y7
Aliases: LERN3, LINGO3
Chromosomal Location: 19q13.42
LINGO3 is a member of the leucine-rich repeat and immunoglobulin-like domain (LRR+Ig) family of transmembrane proteins. It is primarily expressed in the nervous system and plays a role in neurite outgrowth and axon guidance. LINGO proteins are negative regulators of axonal regeneration.
LINGO3 is structurally related to LINGO1 and LINGO2, which are well-established regulators of neuronal survival and myelination. While less studied than LINGO1/2, LINGO3 likely has similar functions in regulating neuronal plasticity and regeneration.
LINGO3 may modulate dopaminergic neuron survival and function. The LINGO1/2/3 family affects neuronal signaling pathways relevant to PD pathogenesis.
| Protein | Interaction | Function |
|---|---|---|
| Nogo Receptor (RTN4R) | Complex formation | Axon growth inhibition |
| NgR1 (RHOA) | Co-receptor | Neuronal signaling |
| LINGO1 | Family interaction | Homologous proteins |
| LINGO2 | Family interaction | Homologous proteins |
| p75NTR (NGFR) | Co-receptor | Signal transduction |
| RhoA | Downstream target | Actin cytoskeleton regulation |
LINGO3 is structurally related to LINGO1 and LINGO2, which are well-established regulators of neuronal survival and myelination. While less studied than LINGO1/2, LINGO3 likely has similar functions in regulating neuronal plasticity and regeneration.
LINGO3 may modulate dopaminergic neuron survival and function. The LINGO1/2/3 family affects neuronal signaling pathways relevant to PD pathogenesis[1].
Decressac et al. LINGO in PD (2012). 2012. ↩︎
Chen et al. LINGO1 antagonism promotes neurite regeneration (2016). 2016. ↩︎