.infobox .infobox-gene {
background-color: #f8f9fa;
border: 1px solid #ddd;
padding: 10px;
width: 300px;
font-size: 0.9em;
}
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | PDE5A |
| Full Name | Phosphodiesterase 5A |
| Chromosome | 4q27 |
| NCBI Gene | 8654 |
| OMIM | 603571 |
| Ensembl | ENSG00000138735 |
| UniProt | O76074 |
| Associated Diseases | Erectile dysfunction, pulmonary hypertension |
PDE5A (Phosphodiesterase 5A) is a cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and/or cAMP. Phosphodiesterases play crucial roles in regulating intracellular signaling pathways, neuronal function, and synaptic plasticity. Dysregulated PDE5A activity has been implicated in neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.
PDE5A hydrolyzes cGMP and is important for smooth muscle relaxation. In brain, it regulates cGMP signaling involved in memory and neuroprotection.
Expressed in platelets, smooth muscle, and brain.