Kcnb2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Kcnb2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNB2 (Potassium Voltage-Gated Channel Subfamily B Member 2) encodes the Kv2.2 potassium channel, closely related to Kv2.1 with distinct expression patterns.
| Property | Value |
|---|---|
| Gene Symbol | KCNB2 |
| Full Name | Potassium Voltage-Gated Channel Subfamily B Member 2 |
| Chromosomal Location | 8q13.3 |
| NCBI Gene ID | 3746 |
| Ensembl ID | ENSG00000182606 |
| UniProt | Q9NSA2 |
The KCNB2 gene encodes Kv2.2, a delayed rectifier potassium channel:
| Disease | Association Type | Key Evidence |
|---|---|---|
| Epilepsy | Risk Modulator | KCNB2 variants associated with epilepsy susceptibility |
| Autism Spectrum Disorder | Risk Modulator | Rare variants found in neurodevelopmental disorders |
KCNB2 shows specific expression:
Kcnb2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Kcnb2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Bocksteins E, et al. J Biol Chem 2009;284:31689-31700