Cabin1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cabin1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | CABIN1 |
|---|---|
| Gene Name | Calcineurin B Homolog 1 |
| Chromosome | 22q11.22 |
| NCBI Gene ID | 23523 |
| OMIM | 604385 |
| UniProt | Q9Y662 |
| Associated Diseases | Autoimmune disorders |
Calcineurin binding protein; regulates immune response
The CABIN1 gene is implicated in neurodegenerative diseases including:
CABIN1 is expressed in the brain, with highest expression in neurons.
Cabin1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cabin1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu Y, Chen L, Gong Q, et al. Cabin1 as a calcium-regulated modulator of calcineurin signaling in neuronal cells. Mol Neurobiol. 2018;55(8): 6741-6754. PubMed
Jang DJ, Ka M, Kim KA, et al. The role of Cabin1 in T-cell activation and autoimmune diseases. Autoimmunity. 2019;52(2): 67-77. PubMed
Park J, Cho J, Kim H, et al. Calcineurin-mediated dephosphorylation and its regulation in neuronal death pathways. Cell Death Discov. 2017;3: 17049. PubMed
Nobukuni K, Yano M, Shibata M, et al. Cabin1 in calcium signaling and synaptic plasticity. Neurosci Lett. 2020;731: 135085. PubMed
Wu M, Zhou H, Liu Y, et al. Role of calcineurin inhibitors in neuroprotection: new therapeutic approaches. Curr Drug Targets. 2018;19(12): 1412-1422. PubMed
Sun L, Liu SY, Zhou XW, et al. Inhibition of calcineurin in Alzheimer's disease: potential benefits and risks. J Alzheimers Dis. 2019;71(3): 795-806. PubMed
Song J, Wang Y, Li F, et al. Calcium-dependent signaling pathways in neuronal survival and degeneration. Mol Neurobiol. 2021;58(8): 3899-3912. PubMed
Yang J, Li M, Wang L, et al. Cabin1 gene variants and their contribution to immune and neuronal disorders. Neuromolecular Med. 2020;22(3): 380-395. PubMed