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| Symbol | CHRM1 |
| Full Name | Cholinergic Receptor Muscarinic 1 |
| Chromosome | 11q12.3 |
| NCBI Gene | 1128 |
| OMIM | 103960 |
| Ensembl | ENSG00000168539 |
| UniProt | P11229 |
| Associated Diseases | Schizophrenia, cognitive function |
CHRM1 (Cholinergic Receptor Muscarinic 1) is a muscarinic acetylcholine receptor that mediates cholinergic signaling in the central and peripheral nervous systems. Muscarinic receptors are G protein-coupled receptors that regulate various neuronal functions including cognition, memory, and motor control. Dysregulated CHRM1 signaling has been implicated in neurodegenerative diseases including Alzheimer's disease.
CHRM1 encodes the M1 muscarinic acetylcholine receptor. It couples to Gq and activates PLC signaling. Important for learning, memory, and hippocampal plasticity. Implicated in AD.
High expression in cortex, hippocampus, and striatum.