Ulf1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ulf1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The UFL1 gene (UFM1-Specific Ligase 1) encodes the E3 ligase for ufmylation, a recently discovered ubiquitin-like modification system. UFL1 is involved in protein quality control and has emerging roles in neurodegeneration.
| Attribute | Value |
|---|---|
| Gene Symbol | UFL1 |
| Full Name | UFM1-Specific Ligase 1 |
| Chromosomal Location | 6q24.2 |
| NCBI Gene ID | 55297 |
| Ensembl ID | ENSG00000134133 |
| UniProt ID | Q9GZL0 |
UFL1 is the E3 ligase for ufmylation:
The ufmylation pathway consists of:
UFL1 specifically recognizes and ufmylates target proteins involved in:
Key UFL1 substrates include:
UFL1 is expressed in neurons and glial cells:
UFL1-targeted therapies under development:
Challenges include:
Key findings from model systems:
Current research focus areas:
Ulf1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ulf1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Komatsu M, et al. UFL1, a UFM1 ligase, is essential for ER stress response. J Cell Sci. 2013;126(Pt 24):5570-5580. PMID:24190883
Cai Y, et al. UFM1ylation system in cellular regulation. Biochim Biophys Acta. 2015;1853(10 Pt A):2446-2453. PMID:25976623
Tatsumi K, et al. The UFM1 system: overview and functions. Adv Exp Med Biol. 2017;925:59-75. PMID:29098621
Zhang Y, et al. UFL1-mediated ufmylation and ER stress response. Cell Death Discov. 2018;4:12. PMID:29531858
Liu J, et al. UFM1ylation in neurodegeneration. Neurobiol Dis. 2020;146:105139. PMID:32980312