Dram1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DRAM1 (DNA Damage Regulated Autophagy Modulator 1) encodes a lysosomal protein that regulates autophagy. It is induced by cellular stress and plays important roles in protein quality control and cell survival in neurodegenerative diseases.
DRAM1 (DNA Damage Regulated Autophagy Modulator 1) is a lysosomal protein that plays a critical role in autophagy and cell survival under stress conditions. It is involved in the regulation of autophagy flux and is implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and ALS.
| Property | Value |
|---|---|
| Symbol | DRAM1 |
| Full Name | DNA Damage Regulated Autophagy Modulator 1 |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 55332 |
| OMIM | 610686 |
| Ensembl ID | ENSG00000138271 |
| UniProt ID | Q8WXX5 |
DRAM1 is a lysosomal membrane protein that acts as a key regulator of autophagy, a cellular process critical for clearing misfolded proteins and damaged organelles. It is transcriptionally regulated by p53 in response to DNA damage.
DRAM1 is expressed in:
| Approach | Status | Notes |
|---|---|---|
| Autophagy enhancers | Research | Increase DRAM1 expression |
| mTOR inhibitors | Approved | Rapamycin increases autophagy |
| AMPK activators | Research | Activate autophagy pathway |
The study of Dram1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.