TRIM46 is a neuron-specific TRIM protein localized to the initial axon segment. It plays critical roles in neuronal polarity and axon initial segment formation, making it important for neuronal excitability.
| Property | Value |
|---|---|
| Gene Symbol | TRIM46 |
| Gene Name | Tripartite Motif Containing 46 |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 92797 |
| OMIM | 616686 |
| UniProt | Q9C0B1 |
TRIM46 is a neuron-specific TRIM protein localized to the initial axon segment. It plays critical roles in neuronal polarity and axon initial segment formation, making it important for neuronal excitability.
The TRIM46 gene is associated with the following neurodegenerative and related diseases:
TRIM46 expression and its relevance to brain function is under active investigation.