Clu — Clusterin (Apolipoprotein J) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Clu — Clusterin (Apolipoprotein J) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | CLU |
| Full Name | Clusterin |
| Chr Location | 8p21.1 |
| NCBI Gene ID | 1115 |
| OMIM ID | 185551 |
| Ensembl ID | ENSG00000120885 |
| UniProt ID | P10909 |
| Encoded Protein | Clusterin (ApoJ) |
| Associated Diseases | Alzheimer's disease, Huntington's disease, ALS, frontotemporal dementia |
CLU encodes clusterin, also known as apolipoprotein J (ApoJ), a multifunctional glycoprotein that is highly expressed in the brain. Clusterin participates in various physiological processes including lipid transport, complement regulation, and apoptosis.
Key normal physiological functions include:
The protein has two subunits:
CLU is one of the most significant genetic risk factors for late-onset AD:
Clusterin is widely expressed in the brain:
The Allen Brain Atlas shows high CLU expression in:
Clu — Clusterin (Apolipoprotein J) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Clu — Clusterin (Apolipoprotein J) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.