WNT10B (Wingless-Type MMTV Integration Site Family Member 10B), also known as WNT-12, is a protein-coding gene encoding a secreted signaling molecule critical for embryonic development, tissue homeostasis, and cellular differentiation. It belongs to the Wnt gene family, which encodes evolutionarily conserved proteins involved in cell-to-cell communication[1].
| Property | Value |
|---|---|
| Gene Symbol | WNT10B |
| Gene Name | Wingless-Type MMTV Integration Site Family Member 10B |
| Aliases | WNT-12, SKT3 |
| Chromosomal Location | 12q13.12 |
| NCBI Gene ID | 7480 |
| OMIM ID | 605397 |
| UniProt ID | Q9Y5Q1 |
| Ensembl ID | ENSG00000169884 |
| Gene Type | Protein Coding |
WNT10B is a secreted glycoprotein (~42 kDa) with characteristic Wnt family features:
The protein is secreted as a lipoglycoprotein and acts as a short-range signaling molecule[2].
WNT10B shows tissue-specific expression:
In the adult brain, WNT10B is expressed in:
WNT10B signaling alterations are implicated in AD pathogenesis:
WNT10B may influence PD through:
Evidence suggests WNT10B involvement in:
WNT10B pathway modulation offers therapeutic opportunities:
Animal models show:
| Protein | Interaction Type | Pathway |
|---|---|---|
| FZD1-10 | Receptor | All pathways |
| LRP5/6 | Co-receptor | Canonical |
| DVL1-3 | Signal transduction | Downstream |
| β-catenin | Transcription factor | Canonical |
| GSK-3β | Kinase | Regulation |
Wang J et al. Wnt10b participates in the regulation of cell proliferation and apoptosis in the spinal cord. Cellular and Molecular Neurobiology. 2015. ↩︎
MacDonald BT et al. Wnt/β-catenin signaling: components, mechanisms, and diseases. Genes & Development. 2009. ↩︎
Zhang X et al. Wnt signaling and Alzheimer's disease: a close connection. Frontiers in Aging Neuroscience. 2015. ↩︎