ASTN1 Gene
ASTN1 (Astrotactin 1) encodes a neuronal membrane protein that functions as a receptor mediating glial-guided neuronal migration during brain development. It plays essential roles in cortical development, hippocampal formation, and cerebellar circuit assembly. ASTN1 continues to be expressed in mature neurons where it contributes to synaptic plasticity and stability. Variants in ASTN1 have been linked to autism spectrum disorder, intellectual disability, and developmental delay. The protein's functions in synaptic adhesion and neuronal connectivity may have implications for understanding neurodegenerative disease mechanisms.
Astrotactin 1 is a neuronal membrane protein that functions as a receptor for neuronal migration during development. It mediates glial-guided migration of neurons in the developing brain and continues to function in mature neurons for synaptic plasticity.
ASTN1 variants are associated with autism spectrum disorder, intellectual disability, and developmental delay. The protein may have roles in synaptic function relevant to neurodegenerative processes.
ASTN1 is expressed during brain development and in mature neurons, with expression in the cerebral cortex, hippocampus, and cerebellum.