TRIM9 is a brain-specific E3 ubiquitin ligase highly expressed in the olfactory bulb and hippocampus. It plays roles in synaptic development, axon guidance, and neuroimmune responses. It interacts with the actin cytoskeleton and postsynaptic density proteins.
| Property | Value |
|---|---|
| Gene Symbol | TRIM9 |
| Gene Name | Tripartite Motif Containing 9 |
| Chromosomal Location | 14q11.2 |
| NCBI Gene ID | 23108 |
| OMIM | 618586 |
| UniProt | Q9C0B1 |
TRIM9 is a brain-specific E3 ubiquitin ligase highly expressed in the olfactory bulb and hippocampus. It plays roles in synaptic development, axon guidance, and neuroimmune responses. It interacts with the actin cytoskeleton and postsynaptic density proteins.
The TRIM9 gene is associated with the following neurodegenerative and related diseases:
TRIM9 expression and its relevance to brain function is under active investigation.