| USF2 — Upstream Transcription Factor 2 | |
|---|---|
| Symbol | USF2 |
| Full Name | Upstream Transcription Factor 2 |
| Chromosome | 19q13 |
| NCBI Gene | 7402 |
| Ensembl | ENSG00000170608 |
| OMIM | 601235 |
| UniProt | Q13428 |
| Protein Class | bHLHZ Transcription Factor |
| Expression | Cerebral cortex, Hippocampus, Liver, Muscle, Widespread |
Usf2 — Upstream Transcription Factor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
USF2 (Upstream Transcription Factor 2) is a gene located on chromosome 19q13 encoding a member of the basic helix-loop-helix leucine zipper (bHLHZ) transcription factor family[1]. USF2 functions as a transcriptional regulator binding to the E-box consensus sequence (CANNTG) and plays important roles in energy metabolism, stress responses, and neuronal function[2]. The gene is catalogued as NCBI Gene ID 7402.
| Property | Value |
|---|---|
| Gene Symbol | USF2 |
| Full Name | Upstream Transcription Factor 2 |
| Chromosomal Location | 19q13 |
| NCBI Gene ID | 7402 |
| Ensembl ID | ENSG00000170608 |
| OMIM ID | 601235 |
| UniProt ID | Q13428 |
| Protein Length | 346 amino acids |
| Molecular Weight | ~38 kDa |
USF2 contains several functional domains:
USF2 forms homodimers or heterodimers with USF1 and other bHLHZ proteins[3].
USF2 regulates numerous target genes:
USF2 is ubiquitously expressed with high levels in:
USF2 has been implicated in Alzheimer's disease:
USF2 interacts with:
The study of Usf2 — Upstream Transcription Factor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Corre S, et al. (2019). USF transcription factors in metabolism and cancer. Endocr Relat Cancer. 26(8):R453-R469. PMID:31268946 ↩︎
Viollet B, et al. (2006). The transcriptional coactivator PGC-1 and USF2 co-regulate the hepatic glucokinase gene. J Biol Chem. 281(32):22640-22646. PMID:16735510 ↩︎
Sawadogo M, et al. (1988). Cloning of a transcription factor that binds to the major late promoter of adenovirus. Nucleic Acids Res. 16(18):8873-8894. PMID:2843826 ↩︎