| Symbol | PRKCE |
| Full Name | protein kinase C epsilon |
| Chromosome | 2p21 |
| NCBI Gene ID | 5581 |
| OMIM | 176975 |
| Ensembl ID | ENSG00000171793 |
| UniProt ID | Q02156 |
| Associated Diseases | Alzheimer's disease, Epilepsy, Cardioprotection |
Protein kinase C epsilon (PKCε) is a novel PKC isoform activated by DAG but calcium-independent. It is involved in cardioprotection, learning and memory, and pain modulation. In the nervous system, PKCε plays roles in synaptic plasticity, neuroprotection against excitotoxicity, and axon guidance. PKCε is neuroprotective in Alzheimer's disease models through inhibition of amyloid-β toxicity and promotion of autophagy. It also modulates GABAergic signaling and is implicated in epilepsy.
Widely expressed with high levels in brain, heart, and lung. Highest expression in hippocampus, cerebral cortex, and cerebellum. Expressed in neurons, astrocytes, and some immune cells.
The PRKCE gene is associated with the following neurodegenerative and neurological conditions:
Alzheimer's disease, Epilepsy, Cardioprotection
This section provides background information on the gene/protein and its role in the nervous system.
This overview section needs to be expanded with relevant scientific information from peer-reviewed sources.