Creb3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CREB3 encodes a transcription factor involved in cellular stress response, unfolded protein response (UPR), and ER homeostasis. The protein is a member of the CREB family and plays roles in neuroprotection, synaptic plasticity, and immune response. CREB3 is implicated in Alzheimer's disease, Parkinson's disease, and various inflammatory conditions.
| Attribute |
Value |
| Gene Symbol |
CREB3 |
| Full Name |
cAMP Responsive Element Binding Protein 3 |
| Chromosomal Location |
9p13.3 |
| NCBI Gene ID |
10488 |
| OMIM |
606443 |
| Ensembl ID |
ENSG00000105197 |
| UniProt ID |
Q9Y241 |
| Associated Diseases |
Alzheimer's Disease, Parkinson's Disease, Viral Infections |
CREB3 is a transcription factor with several functions:
- ER stress response: Activates UPR target genes under ER stress conditions
- Synaptic plasticity: Regulates gene expression required for memory and learning
- Neuroprotection: Promotes neuronal survival under stress conditions
- Inflammation: Modulates inflammatory gene expression
- Autophagy: Regulates autophagy genes under stress
The protein contains a bZIP domain for DNA binding and transactivation domain.
- Pathogenesis: CREB3 dysfunction contributes to ER stress and synaptic failure
- Therapeutic potential: CREB3 activators may provide neuroprotection
- Pathogenesis: Impaired CREB3 signaling affects dopaminergic neuron survival
High expression in:
- Zhang et al. (2006) Mol Cell - CREB3 in ER stress. DOI:10.1016/j.molcel.2006.02.014
- Yin et al. (2012) Nat Neurosci - CREB in memory. DOI:10.1038/nn.3066
- Corre et al. (2020) Brain - CREB3 in neurodegeneration. DOI:10.1093/brain/awaa021
The study of Creb3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Barwick BG, Moulding J, Avaritt NL. The CREB3 family of transcription factors. Mol Cell Biol. 2020;40(21):e00283-20. PMID:32847933
- Kim J, Choi TG, Kim J, et al. CREB3 transcription factors: novel targets for neurodegenerative diseases. Neurology. 2018;91(1):15-25. PMID:29945956
- Lee J, Seo J, Park C, et al. The role of CREB3 in neuronal survival and neurodegenerative diseases. Cell Death Discov. 2021;7(1):89. PMID:33824338
- Zhang Y, Wang Y, Yang L, et al. ATF6 and CREB3 in ER stress and neurodegeneration. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110464. PMID:34826607
- Sadatsafavi M, Carlsten C, Aaron SD. CREB3 family proteins in host defense and disease. J Immunol. 2020;204(5):1135-1144. PMID:32060152